OTC Flying Anxiety Medications to Overcome Fear of Flying (Aviophobia)

If you suffer from flying anxiety, then you’ve probably had stats about how safe flying really is (especially compared to other modes of transportation) or about how rare plane accidents are thrown at you. What most of those people don’t understand, is that you can’t quell phobias and lifelong fears with a couple of statistics. If that was possible, one in six people would not suffer from some sort of fear of flying, and flying anxiety would not be a problem. In this article we look at what flying anxiety is and what the symptoms are, why we suffer from a fear of flying and several over the counter prescription & non-prescription natural medications to overcome flight anxiety.

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Imagine two people sat on a plane traveling together. One is having a panic attack, and the other turns to them and says: “Come on now…calm down. It will all be OK. Don’t you worry, it will all be alright”

The person having the panic attack says: “Stop telling me to calm down. I can’t calm down. Can’t you see I’m stressed? Leave me alone!”

Perhaps this sounds a little bit familiar? Perhaps you are the panicked individual suffering from a lifelong fear of flying? And perhaps you feel that other people don’t really understand?

The good news is that you are not alone! In fact, Boeing and other well respected organizations have carried out many surveys over the past 30 years with a focus on mental reactions to flying, and they estimate that one in every six people have some form of a fear of flying, referred to in the studies as flight anxiety [1].

Other studies show that approximately 40% of the general population experience some degree of aviophobia, an anxiety disorder associated with fear of flying [2]. And an estimated 2.5% to 6.5% of those fearful flyers qualify for a clinical diagnosis of the phobia, one in which a person avoids flying or does so with significant distress [3].

Like with most fears/phobias, the fear of flying is disproportionate to the danger posed (despite what recent Netflix specials like Downfall: The case against Boeing will have you believe). Commercial air travel, within the United States particularly, is extremely safe. A person who took a 500-mile flight every day for a year would have a fatality risk of 1 in 85,000, according to an analysis by Ian Savage, associate chair of the Economics Department at Northwestern University [4]. As a point of comparison: highway travel accounts for 94.4% of national transportation fatalities in the US.

But, of course, statistics are not enough to quell phobias and lifelong fears around flying for a lot of people. In fact, a common reaction to a fear of flying is just to avoid flying as much as possible. There are many high profile celebrities who go out of their way to arrange their personal and professional lives such that they can avoid flying.

But is there a better solution? Can a fear of flying be overcome and/or managed?

In this article we are going to look at several over-the-counter flight anxiety medications, as well as some natural alternatives to OTC flight medications and some popular mental techniques that have proven to help others overcome their fear of flying.

Flight Anxiety Medications Key Takeaways

Without revealing the whole article, here are the most interesting & useful takeways about Flight Anxiety Medications:

  • Aviophobia, the clinical term for flying anxiety or the fear of flight, is a crippling form of anxiety that is classified by the Diagnostic and Statistical Manual of Mental Disorders as a marked aversion towards flying on airplanes or any type of aircraft in general.
  • There are several reasons why people may develop flying anxiety and a fear of flying, but the most common reasons are news and media coverage of flying accidents & tragedies, previous negative experiences while flying or in the run up to a flight, and other pre-existing phobias and anxiety issues.
  • Common over-the-counter medications used for flying anxiety are Dramamine, Ambien, and Benzodiazepines like Xanax. Natural medications include GABA supplements and Melatonin supplements or gummies.

Symptoms of Flying Phobia (Aviophobia)

Aviophobia, the clinical term for “flying phobia” or the fear of flight, is a crippling form of anxiety that is classified by the Diagnostic and Statistical Manual of Mental Disorders as a specific phobia, characterized by a marked aversion towards flying on airplanes or any type of aircraft in general [5].

While the cause of Aviophobia can be varied, people experiencing the phobia may develop any/multiple of the below-mentioned symptoms either before or during an air flight [6]:

  • Shaking or shivering
  • Increased heart rate or heart palpitations
  • Sweating
  • Shortness of breath
  • Dizziness
  • Nausea
  • Clouded thinking or confusion
  • Irritation

For some, even the idea of traveling or booking a ticket for flight travel may induce these symptoms. As there are various causes and triggering factors for developing this phobia, we will discuss the treatment options for Aviophobia below.

Why we suffer from a Fear of Flying in the first place

There are various factors that may contribute to the eventual development of aviophobia. Some of the most common, I would say, are news/media coverage of flying accidents & tragedies and other pre-existing phobias.

News/Media Coverage of Plane Crashes, Hijackings, Malfunctions, etc.

Rory Kennedy, an Oscar-nominated documentary filmmaker, stated in an interview that she made the NetFlix documentary film “Downfall: The Case Against Boeing” due to her ‘primal fear of flying‘.

Kennedy closely tracked the unfolding news story of two back-to-back airplane crashes that took the lives of a total 346 passengers in 2018 [7].

On October 29, 2018, the sky was clear at Jakarta’s Soekarno-Hatta International Airport as Lion Air Flight 610 took off and then, 13 minutes later, fell from the sky. Pilot error was the suspected cause — until five months later when another brand-new Boeing 737 MAX, Ethiopian Airlines Flight 302, met the same fate.

It’s clear to see from Kennedy’s honing in on these crashes (even if her radar for a good story did lead to a surprising exposé around Boeing airlines) that there is an alarming effect that follows media coverage of plane crashes, malfunctions, hijackings, etc.

This is a strange, yet perfectly natural, human reaction to events that are by all metrics, quite rare! It can be argued that increased fear of flying following increased media coverage of an aerial accident is a case of availability bias (also called the availability heuristic).

The availability bias says that our brains tend to make decisions based on two kinds of information:

  • A recent memory
  • A vivid memory

Our brain thinks things that have happened recently or stand out in our minds are more likely to happen again. This is because things that have just happened are top of mind, so it comes to mind quickly and easily. When an event is easier to remember, it becomes easier to imagine it happening again [8].

So, naturally, if somebody isn’t that knowledgeable about the actual risk involved or has little to no experience with flying, and they have recently seen media coverage of crashes or accidents, then it may form preconceived notions about airplanes in their mind.

Other Phobias (acrophobia, claustrophobia, enocholophobia, etc.)

Some people have different pre-existing phobias that may intertwine with aviophobia (a fear of flying). For example, claustrophobia (fear of enclosed spaces), acrophobia (fear of heights), or the fear of terrorism and hijacking [6].

Previous Negative Experiences

Sometimes, a fear of flying can simply be the result of a bad experience in the past, which may have solidified one’s prior fear or may have caused it in the first place. Examples include a previous flight with severe air turbulence, plane controls going haywire, or a forced landing that was jarring (physically and emotionally).

Root Causes

Here’s our latest video covering the root causes (and solutions) of flying anxiety:

A video showing how 1 guy takes over 20+ flights per year, despite being terrified of flying and having huge flying anxiety.

While any one of the listed points could be valid reasons for a fear of flying, every person is different so it’s worth attempting to get to the root of your phobia.

Yuko Nippoda, a psychotherapist and spokesperson for the UK Council for Psychotherapy (UKCP), explained in an interview how a fear of flying often stems from a lack of control [9].

“If you are on a train and you need to get off, you can do so at the next stop. If you’re in a car, you can get out almost anywhere. But once you get on an aeroplane, you cannot leave. This sense of losing all authority over your actions can be very frightening.”

Nippoda added that people are used to feeling their feet on solid ground. Therefore, the idea of floating in the sky can lead to imagining worst-case scenarios.

“If catastrophic situations, such as engine failure, bad turbulence or a hijacking occur, the plane could crash. This fear of death can cause major flight anxiety, even if someone knows deep down those things are extremely unlikely. Their mind can go into overdrive.”

If you can understand that a simple of lack of control, rational or not, can lead to a severe fear of flying, then you can understand that the psychology of our fears can go very deep.

The point is that the start of your journey towards overcoming your fear of flying begins with questioning yourself, delving as deep as possible into your own psyche and understanding what the root of the fear is. Once you understand the root, you can properly address/solve it.

What medications are good for flying anxiety?

Available Over The Counter Medications to Take for Fear of Flying

It is quite common for people to ask their doctor or nurse to prescribe diazepam, or similar benzodiazepine drugs like lorazepam, temazepam or clonazepam, for their fear of flying symptoms or, alternatively, to help sleep during flights.

Ambien For Flying Anxiety

Ambien is the brand (trade) name for Zolpidem, a medication that is commonly prescribed for anxiety-related insomnia and other sleeping difficulties.

In addition to initiating sleep, Ambien has been shown in studies & common usage to help with anxiety. It is a powerful sedative that initiates sleep and alters brain chemistry. The medication works by increasing the neurotransmitter gamma-aminobutyric acid (GABA), a chemical messenger in the brain [14].

The responsibilities of GABA include slowing nerve firing, reducing anxiety levels and muscle tension and helping to initiate sleep. The neurotransmitter also diminishes the impact of brain chemicals which permit a person to fall asleep.

Dramamine For Flying Anxiety

Dramamine, an over-the-counter medication typically used to fight motion sickness, can perform double-duty as an anxiety relief solution for air travel [15].

In a magazine interview the aerospace expert Kathleen Bangs, a former commercial pilot who now teaches flight classes and covers air travel for multiple publications, explained that “many people think the OTC drug Dramamine is only taken to combat nausea, but it’s actually quite effective at inducing drowsiness and reducing anxiety in nervous flyers. I recommend it to passengers as an alternative to that pre-takeoff or in-flight martini. Besides, alcohol dehydrates the body on a cellular level, and the last thing anyone needs while traveling in the ultra-dry air of an airline cabin is more dehydration.

Dramamine is an antihistamine that reduces the effects of natural chemical histamine in the body. It is typically used to treat or prevent nausea, vomiting, and dizziness associated with motion sickness, but the motion sickness drug provides relaxation benefits as well.

Benzodiazepines For Flying Anxiety

Benzodiazepines, typically prescribed under the brand names Valium, Xanax, Restoril, Ativan and Klonopin, are the oldest and most well-known controlled substances for anxiety [11].

Benzodiazepines like Xanax work by decreasing abnormal excitement within the brain. They act on the brain and central nervous system (CNS) to produce a calming effect [12].

Xanax, specifically, slows down the movement of brain chemicals that may have become unbalanced, resulting in a reduction in nervous tension and anxiety. Much like Ambien, Xanax does this by boosting the effects of a natural chemical called gamma-aminobutyric acid (GABA), which is made in the brain [13].

The Case Against Anxiety Medications For Fear of Flying

More recently, several prominent medical sources have spoken out against the use of anxiety medications like benzodiazepines to help with individuals fear of flying issues, with the primary negative points being [10]:

  • Diazepam & Benzodiazepine drugs reduces awareness and reaction times, so in the rare case of an emergency you risk not being able to react to save your life if you have to escape quickly. You may also put other people in danger by getting in their way or making them help you.
  • The use of benzodiazepine drugs can make you sleep in an unnaturally deep sleep. This means you won’t move around as much as during natural sleep so you have a bigger risk of getting a blood clot (Deep Vein Thrombosis or DVT) in the leg or lungs. Blood clots are very dangerous and can kill. This risk is bigger if your flight is longer than 4 hours.
  • Benzodiazepines and similar prescription drugs have short term negative effects on memory, co-ordination, concentration and reaction times, and are (extremely) addictive if used for a long time, with withdrawal leading to fits, hallucinations, agitation and confusion. These drugs have also become widely used drugs of abuse since they first came on the market. Diazepam in the UK & US, for example, is a controlled drug. The prescribing guidelines doctors have to follow say that use to treat short-term “mild” anxiety is inappropriate. They are only to be used short term for a ‘crisis in generalized anxiety’. But if you are having such a crisis you are not likely to be fit to fly. Fear of flying in isolation is not a generalized anxiety disorder.
  • Diazepam, Benzodiazepine and similar controlled drugs are illegal in a number of countries. They may be confiscated or you may find yourself in trouble with law enforcement in some places.

Natural Flying Anxiety Medication Alternatives

Instead of recommending prescription anxiety medications for flight anxiety, experts in the aviation industry have started to recommend more natural, and ideally non-addictive, alternatives to help people with flight anxiety. We personally recommend looking further into Melatonin (although more suited to restful sleep and jetlag symptom reduction), GABA supplements and natural calming solutions.

Melatonin for flying anxiety

Melatonin For Flying Anxiety

Overnight flights can prove particularly stressful for the anxiety-prone, due to the potential for sleep disruption. In these circumstances, the use of melatonin, a natural supplement that can be purchased over-the-counter, may prove useful.

Dr. Khalid Saeed, a Tampa Bay Concierge Doctor, stated in an interview that he [15]:

“Recommend[s] melatonin as a natural supplement to my patients with flight-related anxiety. Melatonin induces sleep and adjusts your circadian clock to help you function better when you reach your destination. I suggest taking melatonin a few days before your trip so that you’re ready to sleep thirty minutes to an hour earlier than normal. It will decrease jet lag if taken close to your target bedtime at your destination, and there are no major side effects to worry about. Plus, your flight will be over before you know it!”

Melatonin is a hormone that your brain typically produces in response to darkness. It helps with the timing of your circadian rhythms (24-hour internal clock) and with sleep. Being exposed to light at night can block melatonin production [16].

Research suggests that melatonin plays other important roles in the body beyond sleep, and study is constantly being carried out on its other benefits. One of the known side-benefits of melatonin is its ability to help with jet lag.

Jet lag affects people when they travel by air across multiple time zones. With jet lag, you may not feel well overall and you may have disturbed sleep, daytime tiredness, impaired functioning, and digestive problems.

Medium-sized reviews from 2010 and 2014 showed that melatonin supplements can have a positive effect on jetlag. Four studies in particular that included a total of 142 travelers, showed that melatonin may be better than a placebo (an inactive substance) in reducing overall symptoms of jet lag after eastward flights. Another study of 234 travelers on eastward flights looked at only sleep quality and found evidence that melatonin may be better than placebo for improving sleep quality [16].

GABA For Flying Anxiety

Gamma-Aminobutyric Acid, shortened to GABA, is a naturally-occurring amino acid that acts as a neurotransmitter within the body. GABA has been shown in numerous studies to have a calming effect, and GABA deficiency is believed to play a part in several anxiety disorders [17].

Studies that used GABA supplementation have found it may have a positive effect on stress and anxiety [18], which would help block the symptoms associated with flying anxiety in a similar way to benzodiazepines like xanax without the associated addiction risk, drowsiness or other side-effects.

Natural Supplements For Flying Anxiety

Some dietary supplements contain a mix of ingredients that support calm and clear, east thinking, which may counteract the negative effects of a fear of flying.

We, of course, like and have recommended the PerformZen Calm Performance Formula supplement, which contains GABA, L-theanine and Magnesium, as well as cognitive-enhancing ingredients Ginkgo Biloba, Vitamin B6 and Theacrine. These ingredients have been shown to help induce a calming effect on the body, as well as keeping the brain as sharp as it needs to be during the more taxing parts of your travel. Learn all about how PerformZen works for flying anxiety here.

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Do The Various Flying Anxiety Medications Actually Work?

If you’ve suffered from a lifelong (or recently developed) fear of flying, know that you are not alone with your fear. One in six people have a fear of flying, according to recent studies [1]. If you are part of this group, suffering from flight anxiety, then you may be considering using benzodiazepines like Xanax, Dramamine, or Ambien to help with your symptoms.

Before you consider using any prescription medications, particularly highly addictive and problematic medications like Xanax, we recommend trying a natural alternative like melatonin, GABA or natural anxiety supplements like our own PerformZen.

Before starting any new medication, ensure that you speak with a licensed medical professional to ensure that there will be no negative interactions with other medications you take, or any unexpected side effects.


Flight Anxiety Medications Frequently Asked Questions

I received some questions from readers who had more specific questions about flight anxiety medications. I’m publishing my responses here to refer people to in future. If you have your own questions, get in contact through the help center.

What can I take to calm anxiety on a plane?

For flight anxiety, medications like benzodiazepines (e.g., Xanax, Ativan) or beta-blockers (e.g., Propranolol) are commonly prescribed to reduce anxiety symptoms. Some people also use over-the-counter options like antihistamines (e.g., diphenhydramine) for their calming and sedative effects. Additionally, supplements like L-theanine or valerian root may provide mild relief for anxiety. I personally recommend PerformZen for flight anxiety, obviously. It’s important to consult your doctor to determine the best option for you, especially if you have any underlying health conditions or are already taking other medications.

Why is my flight anxiety so bad?

Flight anxiety can feel overwhelming due to a combination of factors, including fear of losing control, claustrophobia, turbulence, or concerns about safety. For some, it may be linked to past traumatic experiences, while for others, it can be the fear of being in an unfamiliar or unpredictable situation. Heightened stress before traveling, such as rushing to catch a flight or dealing with airport security, can also intensify anxiety. Understanding your specific triggers and learning coping strategies like deep breathing, mindfulness, or distraction techniques may help ease your anxiety.

Is there a natural sedative for flying?

Yes, several natural sedatives may help with flight anxiety, such as valerian root, passionflower, or magnesium supplements, which can have calming effects. L-theanine, an amino acid found in green tea, is also known for its relaxing properties without causing drowsiness. Lavender oil or aromatherapy can provide a calming effect as well. While these natural remedies may help with mild anxiety, they may not be as effective as medications for more severe cases, so it’s important to discuss them with your healthcare provider to ensure they’re safe for you.


Anita is the owner of PerformanceAnxiety.com (the newest part of the PerformZen family). A seasoned musician and public speaker herself, Anita is no stranger to the very real fear and anxiety that can strike right before a high-pressure situation. That's why Anita is passionate about writing content that helps people learn about and overcome their anxieties & social fears so that they can perform at their best when it counts and live anxiety-free lives.

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